• Diagnostic Programs at Yale Pathology

Yale Pathology Labs offer state-of-the-art diagnostic services reflecting the various subspecialties of more than forty highly qualified physicians. These services include, but are not limited to, Surgical Pathology, Cytology, Dermatopathology, Electron Microscopy and Renal Pathology, Flow Cytometry and Tumor DNA Analysis, Immunohistochemistry and In Situ Hybridization, Hematopathology, Immunology, Eye Pathology, Molecular Diagnostics and Autopsy.

Surgical Pathology is Yale Pathology Labs’ most comprehensive specialty. Our board-certified pathologists are experts in most subspecialty areas and offer complete services for all surgical pathology needs. Areas of intense subspecialty interest include the fields of neuropathology and ophthalmic pathology, gastroenterologic and hepatic pathology, gynecologic and gestational pathology, genitourinary pathology, breast pathology, and reproductive pathology, among others.

• Autopsy Pathology

Determine cause of death, verify clinical diagnoses, assess effectiveness of therapy, clarify clinical findings, address family concerns, train physicians, elucidate unknown disease processes, screen for congenital abnormalities.

• Breast Pathology

Cancer, intraductal carcinoma, in situ carcinoma, estrogen receptors, progesterone receptors, hercep, Her2/neu, conservative therapy, lumpectomy, calcifications, mammographic-pathologic correlation.

• Cytopathology

Early detection of cervical cancer, HPV testing, squamous cell carcinoma, endometrial adenocarcinoma, ovarian adenocarcinoma, bronchial lavages, pneumocystis carinii, aspergillus; fine needle aspirations, lung, liver, thyroid, pancreas; body fluid cytology, pleural, peritoneal, pericardial; mesothelioma, metastatic adenocarcinoma.

• Dermatopathology

Malignant melanoma, melanocytic nevi, cutaneous T cell lymphoma, psoriasis, lichen planus, basal cell carcinoma, Kaposi’s sarcoma, erythema multiforme, leukocytoclastic vasculitis, verruca vulgaris, immunohistochemistry, immunofluorescence.

• Genitourinary Pathology

Prostate, bladder and testicular cancer; immunotherapy of bladder cancer, hormone therapy of prostate hyperplasia/carcinoma; interstitial cystitis, infertility.

• GI and Liver Pathology

Gastroesophageal reflux, Barrett’s esophagus, helicobacter pylori gastritis, stomach cancer, colorectal polyps and cancer, inflammatory bowel disease, chronic hepatitis, cirrhosis, hepatocellular carcinoma.

• Head and Neck, Bone and Soft Tissue

Squamous cell carcinoma of the oral cavity, laryngeal cancer, thyroid disease, parathyroid disease, joint disorders, masses of the soft tissues, sarcomas, osteomyelitis, osteoarthritis, peripheral vascular disease, tumors of the bones, lesions of the extremities.

• Hematopathology & Bone Marrow

Hodgkin’s disease, non-Hodgkin’s lymphoma, lymphoma immunophenotyping/genotyping, immunotherapy, leukemia, myelodysplasia, myeloproliferative disorders, anemia, immune deficiency, opportunistic infections.

• Lung Pathology

Cancer, early lung cancer, screening detected cancers, small cell carcinoma, neuroendocrine carcinoma, adenocarcinoma, bronchial biopsies, thoracoscopic biopsies, mesothelioma, immunohistochemistry.

• Molecular Diagnostics

Lymphoid neoplasms: immunoglobulin gene rearrangements, T cell receptor gene rearrangement, Bcl1 gene rearrangement, Bcl2 gene rearrangement. Solid tumors: K-ras mutational analysis (gastrointestinal, lung and ovarian tumors), p53 mutational analysis (malignant tumors), SYT/SSX rearrangement (synovial sarcoma), Ret/PTC rearrangement (papillary thyroid carcinoma).

• Neuropathology

Inflammatory, degenerative and neoplastic diseases of the central and peripheral nervous system; brain, nerve and muscle biopsies; histochemical and ultrastructural analysis.

• Obstetrics & Gynecology Pathology

Cancer of the ovary, endometrium, and cervix; infertility, placental evaluation, endometrial hyperplasia, dysfunctional uterine bleeding, cervical pap smear, sexually transmitted diseases, cervical dysplasia.

• Ophthalmologic Pathology

Corneal degenerations, transplant rejection, keratoconus, conjunctival proliferations and neoplasms, eye trauma, inflammations of the eyelids, tumors of the eyelids, lesions of the lacrimal system, inflammation and tumors of the eye.

• Pediatric Pathology

Developmental, infectious, metabolic and neoplastic disorders of childhood; Hirschsprung disease, small “blue round cell” tumors, congenital malformations including cardiac and other systems, placental pathology, electron microscopy and biochemical studies of metabolic disorders, immunohistochemistry, and advanced molecular diagnosis.

• Renal and Electron Microscopy

Medical and surgical diseases of the kidney, and kidney transplantation.