Uri  Hershberg, Ph.D.



Associate Research Scientist in Pathology.


Department of Pathology (Pathology Informatics)
Yale University School of Medicine
300 George st. suite #505

New Haven, CT 06510

Office: 203-785-6330
Lab:
Fax:

email: uri.hershberg at yale.edu


Training:
2003-2007 Post-doctoral training, Prof. Mark Shlomchik, Departments of Lab Medicine and Immunology at Yale University, New Haven, CT, USA.
1999-2003 Ph.D. Computational Biology, Thesis: The Emergence of Meaning in Biological Systems. Interdisciplinary Center for Neural Computation (ICNC), Hebrew University of Jerusalem, Israel.
Supervisors:
Prof. Irun Cohen, Department of Immunology, Weizmann Institute of Science, Rehovot; Prof. Sorin Solomon, Department of Theoretical Physics, Racah Institute of Physics, Hebrew University of Jerusalem.
1996-1999 M.Sc. Neural Computation, Hebrew University.
1993-1996 B.Sc. Double major in Biology and Psychology. Cum laude.
Hebrew University of Jerusalem, Israel.


Expertise:
Computational Biology, Immunology, Neurobiology, Cognitive Science.


Research Interests:
I am a theoretical biologist. The common theme of my research and interests is the place of context in the creation of meaning in biological interactions. I study this question mostly through studies of the function of B cell and T cell repertoires during affinity maturation. Lately I have also begun to study the early temporal dynamics of the anti-viral response in dendritic cells. As opposed to my previous research, that related receptor specificity to cell populations, this research is involved more at the level of intra-cellular signaling and transcription.


Professional Service:


Other Links:

my more detailed website

Selected Publications:

Zaslavsky, E*., Hershberg, U.*, Seto, J., Pham, A.M., Marquez, S., Duke, J.L., Wetmur, J.G., tenOever, B.R., Sealfon, S.C. and Kleinstein, S.H. (2010) Antiviral response dictated by choreographed cascade of transcription factors Journal of Immunology, Vol.184 issue 6 pp. 2908-17. (*Equal contribution first author)

Anderson, S.M., Khalil, A., Uduman, M., Hershberg, U., Louzoun, Y., Haberman, A.M., Kleinstein, S.H., and Shlomchik M.J.,(2009 in press) Taking Advantage: Selection of High Affinity B cells in the Germinal Center Is Controlled By Death, Not Proliferation Journal of Immunology, Vol.183 issue 11 pp. 7314-25.

Herlands, R.A., Christensen, S. R., Sweet, R.A., Hershberg, U. and Shlomchik M,J. (2008) Antigen-Driven Activation of Autoreactive B Cells That is T Cell-Independent and TLR-Dependent, Immunity Vol. 29 Issue 2 pp. 249-60.

Hershberg, U., Uduman, M., Shlomchik, M.J. and Kleinstein S.H. (2008) Improved methods for detecting selection by mutation analysis of Ig V region sequences, International Immunology Vol 20 issue 5 pp. 683-694, (Cover article).

Hershberg, U. and Shlomchik, M.J. (2006) Differences in potential for amino acid change following mutation reveals distinct strategies for kappa and lambda light chain variation. PNAS Vol. 103 no.43 pp. 15963-8.

Hershberg U., Solomon S. and Cohen, IR. (2003) What is the basis of the immune system's specificity? Mathematical Modelling & Computing in Biology and Medicine, (V.Capasso Ed.), pp. 377-384 The MIRIAM Project Series, Progetto Leonardo, ESCULAPIO Pub. Co., Bologna, Italy.

Hershberg U., Louzoun, Y., Atlan H. and Solomon, S. (2001) HIV time hierarchy: Winning the war while loosing all the battles. Physica A: 289 (1-2) pp.178-190, also placed on the net at xxx.lanl.gov (Nonlinear Sciences-Adaptation and Self Organizing Systems).

Hershberg U. and Efroni S. (2001) The immune system and other cognitive systems. Complexity, Vol. 6 issue 5 pp.14-21.

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This page was last modified on: 03/24/2010