Christine L. Howe, Ph.D.



Research Scientist in Pathology.



Department of Pathology
Yale University School of Medicine
P.O. Box 208028
Yale Cancer Center, NSB 294
New Haven, CT 06520-8028

Office: 203-785-4097
Lab:
Fax: 203-785-4116

email: christine.howe@yale.edu


Training:
Post-Doc (cell biology) Yale Univ. School of Medicine, New Haven, CT, 1983-86
Ph.D. (Biology) Yale Univ., New Haven, CT 1983
M.S. (Biology) George Washington Univ., Washington, DC, 1978
B.A. (Biol. Sciences) University of California, Davis, CA, 1973

Expertise:
patholgenesis of breast cancer.

Research Interests:
One of the potentially most rewarding features of cancer research is the possibility that advances in the basic understanding of the disease will translate into improved diagnostic methods, earlier detection of disease, accurate prognostic evaluation, and ultimately advances in therapy. The Program for Critical Technologies in Molecular Medicine synergizes basic research and the bridging of basic and clinical research in oncology by providing investigators with essential services including i) access to fresh, frozen, and/or paraffin-embedded human tissues in which both the pathology and clinical status are well characterized, and which are collected and distributed in an ethical manner; ii) a wide range of sophisticated histologic, immunologic, genetic, and molecular analyses of relevance to cancer; iii) an increasingly comprehensive retrospective and longitudinal follow-up database of the clinical course of patients whose tissues have been accessed through the PCTMM.

Tissue Procurement and Tissue Prodect distribution; Material Transfer Agreements, Pathogenesis of Breast Cancer; Race differences in breast cancer survival. Pathogenesis and treatment of TS, OCD, and related disorders. Organochlorine compounds/risk of breast cancer. Other Interests: Biomedical Research Ethics, Science Education

Professional Service:
American Association for the Advancement of Science
Appled Research Ethics National Association
Member, U.S. Coast Guard Auxiliary

Other Links:

Program for Critical Technologies
Community of Science (COS) Database

Selected Publications:

Dillon, D.A., Howe, C.L., Bosari, S., and Costa, J. The molecular biology of breast cancer: Accelerating clinical applications. Crit. Rev. Oncogenesis 9(2):125-140 (1998).

DiGiovanna, M.P., Chu, P., Davison, T.L., Howe, C.L., Carter, D., Claus, E.B., Stern, D.F. 1998. Active signalling by HER-2/neu in a subpopulation of HER-2/neu overexpressing DCIS: clinico-pathologic correlates.

Howe, C.L. (co-chair and editor), 1997. ìModel Consent Forms & Related Information on Tissue Banking from Routine Biopsies,î Public Responsibility in Medicine and Research [PRIM&R] and Applied Research Ethics National Association [ARENA] publication.

Speicher, M.R., Howe, C., Crotty, P., Du Manior, S., Costa, J., Ward, D.C. Comparative genomic hybridization detects novel deletions and amplifications in head and neck squamous cell carcinomas. Cancer Res. 55:1010-1013 (1995).

Costa, J., Howe, C.L., Emanuel, J.R. Digestive System. In Advanced Diagnostic Methods in Pathology, Saunders, 1995.







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This page was last modified on: 09/17/2008