Xudong  Huang, Ph.D.



Associate Research Scientist in Pathology.


Department of Pathology
Yale University School of Medicine
P.O. Box 208023
310 Cedar St., LH 208
New Haven, CT 06520-8023

Office:
Lab: (203) 785-2779
Fax:

email: xudong.huang@yale.edu


Training:
Postdoc, Cell Biology, The Hospital for Sick Children, and Protein Structure, University of Toronto, Canada

Ph.D. Molecular Genetics, Experimental Endocrinology, Lund University, Sweden

M.Sc. Biochemistry, Helsinki University, Finland

B.S. Biochemistry, Sichuan University, China





Expertise:
Gene expression profiling and gene/disease association
Protein expression, purification, crystallization and engineering

Research Interests:
Epigenetic regulation of diabetes and cancer

Professional Service:


Other Links:


Selected Publications:

Huang, X., Finerty P, Jr., Walker JR, Butler-Cole C, Vedadi M, Schapira M, Parker SA, Turk BE, Thompson DA, Dhe-Paganon S. Structural insights into the inhibited states of the Mer receptor tyrosine kinase. J Struct Biol. 2009, 165:88-96.

Foster LJ, Rudich A, Talior I, Patel N, Huang, X., Furtado M, Bilan PJ, Mann M, Klip A. Insulin-dependent interactions of proteins with Glut4 revealed through stable isotope labeling by amino acids in cell culture (SILAC). J Proteome Research. 2006, 5:64-75.

Huang, X., Vaag A, Carlsson E, Hansson M, Ahren B, Groop L. Impaired cathepsin L gene expression in skeletal muscle is associated with Type 2 diabetes. Diabetes.2003, 52:2411-8.

Huang, X., Hansson M, Laurila E, Ahren B, Groop L. Fat feeding impairs glycogen synthase activity in mice without effects on its gene expression. Metabolism.2003,52:535-9.

Huang, X., Vaag A, Hansson M, Groop L. Down-regulation of insulin receptor substrates (IRS)-1 and IRS-2 and Src homologous and collagen-like protein Shc gene expression by insulin in skeletal muscle is not associated with insulin resistance or type 2 diabetes. J Clin Endocrinol Metab. 2002,87:255-9.

Huang, X., Vaag A, Hansson M, Weng J, Laurila E, Groop L. Impaired insulin-stimulated expression of the glycogen synthase gene in skeletal muscle of type 2 diabetic patients is acquired rather than inherited. J Clin Endocrinol Metab. 2000, 85:1584-90.

Huang, X., Eriksson KF, Vaag A, et al. Insulin-regulated mitochondrial gene expression is associated with glucose flux in human skeletal muscle. Diabetes. 1999, 48:1508-14.

Huang, X., Orho M, Lehto M, Groop L. Lack of association between the Gly40Ser polymorphism in the glucagon receptor gene and NIDDM in Finland. Diabetologia. 1995, 38:1246-8.

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This page was last modified on: 06/15/2010