Michael  Kashgarian, M.D.

Training:

M.D. Yale University School of Medicine, New Haven, CT, 1958
B.A. (Chemistry) New York University, NY, NY, 1954
Residency: Barnes Hospital, St. Louis (Medicine); Yale New Haven Hospital (Pathology)
Fellowship: University of Göttingen, Germany

Expertise:

Transport ATPases, Ischemic Cell Injury, Heat Shock proteins, Mechanisms of Glomerular Sclerosis. Clinical Interestss: renal pathology, diagnostic electron microscopy, genetic pathology. Other interests include advanced imaging techniques, confocal microscopy, image analysis, vital microscopy.

Research Interests:

Research in this laboratory is directed in three main investigative areas. We study the structural and functional characteristics of transporting epithelia, in particular the cellular mechanisms involved in adaptive changes in response to steroid hormones and changes in the external ionic milieu. The second area of investigation is of the mechanisms involved in the recovery from acute renal failure. These studies concentrate on the contribution of the cytoskeleton to the reorganization of the micro domain distribution of Na,K-ATPase as well as investigating the role of the synthesis and recycling of integral membrane proteins and the contribution of heat shock proteins in this process. Finally, we are also investigating the factors involved in the initiation and progression of glomerulus scarring by defining the pathogenetically relevant parameters of progressive glomerular injury.

Renal Disease, renal transport and ischemia, heat shock proteins, diabetic nephropathy, Electron Microscopy; juvenile diabetes. Cellular disruption and restitution. Diabetes endocrinology.

Professional Service:

Alpha Kappa Kappa
American Association for the Advancement of Science
American Heart Assoc: Council on the Kidney in Cardiovascular Disease
American Physiological Society
American Society of Clinical Pathologists (Fellow) (Advisory Council 1978-85)
College of American Pathologists (Fellow) (Alternate Delegates 1985-present)
United States and Canadian Academy of Pathology
International Society of Nephrology
Renal Pathology Society, President 1993-94
American Society of Nephrology
Salt and Water Club
American Medical Association
CT State Medical Society: Member, House of Delegates; Chairman of Committee on Organ and Tissue Transfers (1987-1990)
New Haven County Medical Assoc: Member Board Of Governers (1985-present); former
Secretary, Vice President, President
CT Society of Pathologists: Executive Committee 1972-present; also Secretary-Treasurer and President
Universities Assoc. for Research and Education in Pathology: Board of Directors (1989-94) on Task Force on Environmental, Toxic and Occupational Diseases.

Federation of Am. Societies for Experimental Biology
German Society of Nephrology
Board of Directors, New Haven Symphony Orchestra
Vice President, Connecticut Fund for the Environment
English Speaking Union
New Haven Historical Society

Selected Publications: