Jung H. Kim, M.D.



Professor Emeritus of Pathology and
Senior Research Scientist.

Department of Pathology
Yale University School of Medicine
P.O. Box 208023
310 Cedar St., LH 219
New Haven, CT 06520-8023

Office: 203-785-6463
Lab:
Fax: 203-737-1064

email: jung.kim@yale.edu


Training:
M.D. College of Medicine, Pusan National University, Pusan, Korea, 1964
Undergraduate: College of Liberal Arts & Sciences, Pusan National University, Pusan, Korea, 1960
Yale University School of Medicine (Neuropathology) 1973-76.
Albert Einstein College of Medicine, Bronx Municipal Hospital Center, NY (anatomical and clinical) 1969-73
Downstate Univeristy, Kings County Medical Center, Brooklyn, NY (Pediatrics) 1968-69.


Expertise:
neuropathology; surgical pathology (brain tumors, epilepsy, muscle); autopsy. dementia including Alzheimer's disease.

Research Interests:
Hippocampal sclerosis (neuronal loss and gliosis) plays a complicated role in epilepsy: hippocampal sclerosis occurs due to epilepsy, but, in turn, the sclerotic hippocampus appears to be responsible for epileptogenesis. We are looking into the role of hippocampal neurons and glial cells in epilepy through neuronal and glial density studies in surgically resected hippocampi from intractable epilepsy patients. My second research interest is the role of calpains in CNS degenerative disorders, epilepsy and AIDS. All three conditions just mentioned are believed to have neuronal damages, at least in part, due to excitotoxicity, which may acitivate calpains, a family of Ca++ dependant proteases. Calpains, once activated, cleave spectrin, generating the spectrin breakdown product (BDP), and involvement of calpains is determined by detecting spectrin BDP in the CNS tissue.


Professional Service:
American Association of Neuropathologists
Society for Neuroscience
American Society of Clinical Pathologists
American Epilepsy Society

Other Links:

Surgical Pathology
Autopsy Pathology

Selected Publications:

Kim, J.H. Pathology of Epilepsy. Review. Experimental and Molecular Pathology 70:345-367, 2001

Spencer, S.S., Novotny, E., deLanerolle, N, Kim, J. Mesial Temporal Sclerosis: electroclinical and pathological correlations and applications to limbic epilepsy in childhood (Chapter 5). In: Limbic Seizures. Avanzini, G., Beaumanoir, A & Mira, L (eds), JonhLibbey & Company, Ltd,. pp41-54, 2001

Petroff, OAC, Errante, LD, Rothman, DL, Kim, JH, Spencer, DD. Glutamate-glutamine cycling in the epileptic human hippocampus. Epilepsia 43:703-710, 2002

Huh, G-Y, Glantz, SB, Je, S, Morrow, JS, Kim, JH. Calpain proteolysis of alpha II spectrin in the normal adult human brain. Neurosci. Lett. 316:41-44, 2001.

Uranish, R, Baev, NI, Ng, P-Y, Kim, JH, Awad, IA. Expression of endothelial cell angiogenesis receptors in human cerebral vascular malformations. Neurosurgery 48:359-368. 2001

Spencer SS, Kim J, deLanerolle N, Spencer DD. Differential neuronal and glial relations with parameters of ictal discharge in mesial temporal lobe epilepsy. Epilepsia 1999 Jun;40(6):708-12

Wong, J.H., Kim, J.H., Awad, I.A. Pathological features of spinal vascular malformations. (Chapter 2). In:Spinal vascular malformations. Barrow, D.L. and Awad, I.A. (eds). Am. Assoc. Neurol. Surgeons, Park Ridge, pp9-22, 1999.



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This page was last modified on: 07/02/2009