Steven H. Kleinstein, Ph.D.



Assistant Professor of Pathology.


Department of Pathology
Yale University School of Medicine
300 George Street
Suite 505
New Haven, CT 06511

Office: 203-785-6685
Lab: 203-785-6685
Fax:

email: steven.kleinstein@yale.edu


Training:
B.A.S., Computer Science (1994), University of Pennsylvania
Ph.D., Computer Science (2002), Princeton University
Computational Scientist (2002-2003), Physiome Sciences, Princeton, NJ
Research Staff (2003-2006), Program in Integrative Information, Computer and Application Sciences, Princeton University

Expertise:
computational immunology, systems biology, disease/tissue/pathway/process modeling and simulation, statistical and model-based analysis of experimental and clinical data.

Research Interests:
Our group combines techniques from dynamic modeling, systems biology and bioinformatics to better understand the immune response. We are particularly interested in the generation and selection of high affinity B lymphocytes in germinal centers during immune and autoimmune responses. As part of PRIME (Program for Research on Immune Modeling and Experimentation), we are developing mathematical models to elucidate the viral mechanisms of induction and subversion of type 1 interferon responses and maturation of dendritic cells by Category A-C viral pathogens. More details are available on our laboratory website (see link below).

Professional Service:
Scientific Advisory Board, Immunetrics, Pittsburgh, PA
Member, American Association of Immunologists
Member, International Society for Computational Biology
Member, New York Academy of Sciences
Member, Society for Mathematical Biology


Other Links:

Kleinstein Lab Website

Selected Publications:

Elena Zaslavsky, Uri Hershberg, Jeremy Seto, Alissa M. Pham, Susanna Marquez, Jamie L. Duke, James G. Wetmur, Benjamin R. tenOever, Stuart C. Sealfon and Steven H. Kleinstein. "Antiviral response dictated by choreographed cascade of transcription factors". The Journal of Immunology (2010) Mar 15;184(6):2908-17.

Steven H. Kleinstein. "Getting Started in Computational Immunology". PLoS Computational Biology (2008) 4(8): e1000128 doi:10.1371/journal.pcbi.1000128

Uri Hershberg, Mohamed Uduman, Mark J. Shlomchik and Steven H. Kleinstein. "Improved methods for detecting selection by mutation analysis of Ig V region sequences". International Immunology, (2008) May;20(5):683-94. PMID: 18397909

Two levels of protection for the B cell genome during somatic hypermutation. Man Liu, Jamie L. Duke, Daniel J. Richter, Carola G. Vinuesa, Christopher C. Goodnow, Steven H. Kleinstein and David G. Schatz. Nature (2008) Feb 14;451(7180):841-5.

Anja E. Hauser, Tobias Junt*, Thorsten R. Mempel*, Michael W. Sneddon*, Steven H. Kleinstein*, Sarah E. Henrickson, Ulrich H. von Andrian, Mark J. Shlomchik, and Ann M. Haberman." Definition of Germinal-Center B Cell Migration In Vivo Reveals Predominant Intrazonal Circulation Patterns". Immunity (2007) Vol. 26, 655-667.

Reuma Magori Cohen, Yoram Louzoun and Steven H. Kleinstein. "Mutation parameters from DNA sequence data using graph theoretic measures on lineage trees". Bioinformatics, (2006) Vol. 22 No. 14, e332-e340.

* authors contributed equally



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This page was last modified on: 06/15/2010