Jie  Li, M.D., Ph.D.



Research Scientist in Pathology.


Department of Pathology
Yale University School of Medicine
P.O. Box 208023
310 Cedar Street, LH413
New Haven, CT 06520-8023

Office: 203-737-3651
Lab:
Fax: 203-785-6899

email: li.jie@yale.edu


Training:
2004-2008 Research Fellow
Surgical Neurology Branch
NINDS, NIH
Bethesda, MD

2001-2004 Visiting Fellow
Section of Molecular Endocrinology
ERRB, NICHD, NIH
Bethesda, MD

2000- 2001 Associate Professor and Staff Physician
Department of Neurosurgery
Tianjin Medical University General Hospital
Tianjin, China

1995-1998 Ph.D. (Molecular Neuro-Oncology)
Tianjin Medical University
Tianjin, China

1988-1995 M.D. (Neurosurgery)
Tianjin Medical University
Tianjin, China


Expertise:
Molecular Neuro-Oncology
Proteomics
Selective tissue dissection
Neurosurgery



Research Interests:
Translational Research: discover bio-markers, therapeutic targets using clinical specimens.

Brain tumor therapy: use combined gene therapy, immuno-therapy and small molecules.

Technology improvement and invention: crossing the fields of proteomics, microdissection, genomics, tissue array, neurosurgical instruments, drug delivery, etc. Collaboration is extremely welcome and considered as a MUST!


Professional Service:
1998~ peer reviewer, Natural Science Foundation of China, Beijing, China
2007~ peer reviewer, for journals like Annals of Neurology, Carcinogenesis, Technology in Cancer Research&Treatment, etc.

Scientific Grants and Awards:

2007-2008 4th Applicant, NIH Intramural AIDS targeted antiviral program (IATAP). Regulation of Host Genes in Primary Human Monocyte/Macrophages Studied by in vitro Electroporation of HIV and Cellular Genes. Maryland, USA
2005 Science and Technology Award. Tianjin, China
2001~2004 1st Applicant, National Natural Science Foundation of China. The study of IGF-PI3K/PBK signal pathway adjusted by PTEN.
2000~2003 2nd Applicant, National Natural Science Foundation of China. The study of glioma gene expression in Chinese patients.
2000~2003 1st Applicant, Natural Science Foundation of Tianjin Bureau of Public Health. AKT2 gene and glioma therapy.
2000~2003 1st Applicant, Science Foundation of 21 Century Young Scientist (by Tianjin Municipal Science and Technology commission). The transcriptional regulation of cell cycle by AKT2 gene.
2000 21th Century Young Scientist Award. Tianjin, China
1998~2001 3rd Applicant, National Natural Science Foundation of China. Connectin protein and glioma.
1997~2000 1st Applicant, Natural Science Foundation of Tianjin Education Committee. Inhibitory effect of antisense IGF-1 on growth of glioma.


Other Links:


Selected Publications:

Jeffrey Helgager, Jie Li, Irina Lubensky, Russell Lonser and Zhengping Zhuang. Troglitazone Reduces Glyoxalase I Protein Expression in Glioma and Potentiates the Effects of Chemotherapeutic Agents. J Oncol. 2010;2010:373491. Epub 2010 May 4.

Tsai-Morris CH, Sheng Y, Gutti R, Li J, Pickel J, Dufau ML. Gonadotropin-regulated testicular RNA helicase (GRTH/DDX25) gene: Cell-specific expression and transcriptional regulation by androgen in transgenic mouse testis. J Cell Biochem. 2010 Jan 27.

Sheng Y, Tsai-Morris CH, Li J, Dufau ML. Lessons from the gonadotropin-regulated long chain acyl-CoA synthetase (GR-LACS) null mouse model: a role in steroidogenesis, but not result in X-ALD phenotype. J Steroid Biochem Mol Biol. 2009 Mar;114(1-2):44-56.

Jagannathan J, Li J, Szerlip N, Vortmeyer AO, Lonser RR, Oldfield EH, Zhuang Z. Application and implementation of selective tissue microdissection and proteomic profiling in neurological disease. Neurosurgery. 2009 Jan;64(1):4-14

Mehta GU, Shively SB, Duong H, Tran MG, Moncrief TJ, Smith JH, Li J, Edwards NA, Lonser RR, Zhuang Z, Merrill MJ, Raffeld M, Maxwell PH, Oldfield EH, Vortmeyer AO. Progression of epididymal maldevelopment into hamartoma-like neoplasia in VHL disease. Neoplasia. 2008 Oct;10(10):1146-53.

Li J, Okamoto H, Yin C, Jagannathan J, Takizawa J, Aoki S, Gl�sker S, Rushing EJ, Vortmeyer AO, Oldfield EH, Yamanaka R, Zhuang Z. Proteomic characterization of primary diffuse large B-cell lymphomas in the central nervous system. J Neurosurg. 2008 Sep;109(3):536-46.

Li J, Yin C, Okamoto H, Mushlin H, Balgley BM, Lee CS, Yuan K, Ikejiri B, Glasker S, Vortmeyer AO, Oldfield EH, Weil RJ, Zhuang Z. Identification of a novel proliferation-related protein, WHSC1 4a, in human gliomas. Neuro Oncol. 2008 Feb;10(1):45-51. Epub 2008 Jan 8. Erratum in: Neuro Oncol. 2008 Apr;10(2):231.

(Book Chapter) Zhengping Zhuang, Jie Li, Harry Mushlin, Alexander O. Vortmeyer: Selective Tissue Procurement for Renal Tumor Proteomics. In: Thongboonkerd V (ed) Renal and Urinary Proteomics: Methods and Protocols. Wiley-VCH, 2009, pp 131-147

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This page was last modified on: 08/26/2010