Vincent T. Marchesi, M.D., Ph.D.



Anthony N. Brady Professor of Pathology and Professor of Cell Biology.


Department of Pathology
Yale University School of Medicine
P.O. Box 208023
295 Congress Ave., BCMM109
New Haven, CT 06520-8023

Office: (203) 737-2263
Lab:
Fax:

email: vincent.marchesi@yale.edu


Training:
M.D. Yale University School of Medicine, New Haven, CT, 1963
Ph.D.(Experimental Pathology)/Oxford University, Oxford, UK, 1961
B.A. Yale College, New Haven, CT, 1957

Expertise:
Pathology of endothelial neovascularization, proteinase modulation during T cell-endothelial Dhesion, role of NO in angiogenesis, adaptive mechanism of developing brain.

Research Interests:
We investigate the regulation of cell division. Among the questions to be answered, if we are to understand mitosis at the molecular level, are (1) what triggers the disassembly of the interphase cytoskeleton, (2) what organizes the assembly of the nascent mitotic spindle, (3) how do the mitotic spindle tubules make contact with and then help orient the paired chromatids along the metaphase plate, and (4) what triggers first the anaphase separation of the sister chromatids and then their segregation to each of the progeny. We have developed simple methods for the isolation of synchronized cultured cells that progress through one complete mitotic cycle in a 70 min. period. These cells can be studied both morphologically and biochemically, and they can be transfected with specific genes whose expression can be controlled. A long term goal of this work is to identify specific inhibitors that may be used to control neoplastic proliferation.

Mechanism of mitosis, scaffolding,
Research Interest: Pathol. of endothelial neovascularization, proteinase modulation during T cell-endothelial adhesion, role of NO in angiogenesis, adaptive mechanism of developing brain.

Professional Service:
Editor-in-Chief, The FASEB Journal
Editor, Laboratory Investigation Journal
Memberships:
American Association of Immunologists
American Society for Investigative Pathology
American Society for Biological Chemistry
American Society for Cell Biology
Biophysical Society

1968-72 Member, Biochemistry and Chemical Carcinogenesis Study Section, American Cancer Society
1973 Scientific Consultant, Anna Fuller Fund, Yale University
1972-74 Member, Molecular Biology Study Section, National Institutes of HealthBoard of Scientific
1975-81 Advisors, Sloan Kettering Research Institute
1981-82 Board of Scientific Advisors, New York Blood Center
1991-93 Board of Scientific Counselors of the National Institute of Arthritis and Musculoskeletal and Skin Diseases


Other Links:

Boyer Center
Community of Science (COS) Database

Selected Publications:

Marchesi, V.T., Ngo, N. 1993. In vitro assembly of multi-protein complexes containing alpha, beta, and gamma tubulin, Hsp 70 and elongation factor 1-alpha. Proc. Natl. Acad. Sci. 90:3028-3032.

Huang, J.P., Tang, C.J., Kou, G.H., Marchesi, V.T., Bentz, Jr. E.J. and Tang, T.K. 1993. Genomic structure of the locus encoding protein 4.1 Journal Biol. Chem. 268:3758-3766.

Winkelmann, J.C., Chang, J.G., Tse, W. T., Scarpa, A.L., Marchesi, V.T., and FOrget, B.G. 1990. Full-length sequence of the cDNA for human erythroid b specrtrin. J. Biol. Cehm ., 265:11827-11832.

Sahr, K. E., Laurila, P., Kotula, L., Scarpa, A. L., Coupal, E., Leto, T. L., Linnenbach, A. J., Winkelmann, J. C., Speicher, D. W., Marchesi, V. T., Curtis, P. J. and Forget, B. G.. 1990. The complete cDNA and polypeptide sequences of human erythroid a-spectrin. J. Biol. Chem., 265:4434-4443.

Tang K. Tang, Qin, Z., Leto, T.L., Marchesi, V.T., and Benz, E.J., Jr.. 1990. Human erythroid and non-erythroid cells is composed of multiple isoforms with novel sizes, functions and tissue specific expression. Cell Molec. Biol. of Normal and Abnormal Erythroid Membranes, 43-59.

Tang K. Tang, Qin, Z., Leto, T.L., Marchesi, V.T., and Benz, E.J., Jr.. 1990. Heterogeneity of mRNA and protein products arising from the protein 4.1 gene in erythroid and non-erythroid tissues. J.Cell Biol. 110: 617-624.





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This page was last modified on: 09/17/2008