Don X. Nguyen, Ph.D.



Assistant Professor of Pathology


Department of Pathology
Yale University School of Medicine
P.O. Box 208023
310 Cedar St, BML 348B
New Haven, CT 06520-8023

Office: 203-737-4514
Lab: 203-785-6496
Fax:

email: don.nguyen@yale.edu


Training:
B.S., McGill University, Montreal, Quebec, Canada. 1998.
Ph.D., University of Rochester, Rochester, NY. 2004.
Post-doctoral fellow, Memorial Sloan-Kettering Institute, with Joan Massague, New York, NY. 2004-9.


Expertise:
Biology of metastasis, lung cancer, tumor-microenvironment interactions, cancer genetics.

Research Interests:
Cancer metastasis remains an unresolved clinical and biological problem. This is particularly true in the case of thoracic malignancies, which can spread aggressively to multiple distant organs with limited opportunity for effective therapeutic intervention. Metastatic lung cancer cells are believed to acquire complex biological properties by deregulating pleiotoropic genetic or epigenetic programs and interacting with their microenvironment. My laboratory is interested in uncovering the molecular and biological determinants of metastasis by different lung cancers, including lung adenocarcinoma. In this endeavor, we utilize a variety of approaches such as animal modeling, cell culture assays, bioinformatics, and clinical validation.

Professional Service:


Other Links:

Nguyen Lab

Selected Publications:

Kim, M-Y., Oskarsson, T., Acharyya, S., Nguyen, D.X., Zhang, X-F., Norton, L., and Massague, J. Tumor self-seeding by circulating cancer cells. Cell, 139 (7): 1315-1326 (2009).

Nguyen, D.X., Chiang, A.C., Zhang, H.F.X., Kim, J.Y., Kris, M.G., Ladanyi, M., Gerald, W.L., and Massague, J. WNT/TCF signaling through LEF1 and HOXB9 mediates lung adenocarcinoma metastasis. Cell, 138(1): 51-62 (2009).

Bos, P.D., Zhang, H.F.X., Nadal, C., Shu. W., Gomis. R.R., Nguyen, D.X., Minn, A.J., Van de Vijver, M., Gerald, W.L., Foekens, J.A., and Massague, J. Genes that mediate metastasis through the blood-brain barrier. Nature, 459: 1005-9 (2009).

Gupta, G.P*, Nguyen, D.X.*, Chiang, A.C., Bos, P.D., Kim, J.Y., Nadal, C., Shu, W.,Gomis, R.R., Todorova-Manova, K., and Massague, J. Mediators of vascular remodeling co-opted for sequential steps in lung metastasis. Nature, 446: 765-770 (2007). *Authors contributed equally.

Minn, A.J., Gupta, G.P., Padua, D., Bos, P.D, Nguyen, D.X., Kreike, B., Nuyten, D., Zhang, Y., Wang, Y., Foekens, J.A., van de Vijver. M., and Massague, J. Lung Metastasis Genes Couple Breast Tumor Size and Metastatic Spread. PNAS, 104, 6740- 6745 (2007).

Nguyen D.X., Bos P.D., and Massague, J. Metastasis: from dissemination to organ specific colonization. Nature Reviews Cancer, 9(4): 274-284 (2009).

Nguyen, D.X. and Massague, J. Genetic Determinants of Cancer Metastasis. Nature Reviews Genetics: 8 (5), 341-352 (2007).



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This page was last modified on: 05/28/2010