 Jordan S. Pober, M.D., Ph.D.
Professor and Vice Chair of Immunobiology for Human and Translational Immunology;
Professor of Dermatology and Pathology.
Department of Immunobiology for Human and Translational Immunology
Yale University School of Medicine
P.O. Box 208023
295 Congress Ave. BCMM 454
New Haven, CT 06520-8023
Office: (203) 737-2292
Lab:
Fax: (203) 737-2293
email: jordan.pober@yale.edu
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Training:
- 1971 - B.A. Biology, Chemistry, History, Haverford College, Haverford, PA
1977 - M.D. School of Medicine, Yale University, New Haven, CT
1977 - Ph.D. Molecular Biophysics/Biochemistry, Yale University, New Haven, CT
1977-1978 Resident, Pathology, Yale-New Haven Hospital, New Haven, CT
1978-1980 Postdoctoral Fellow, Biochemistry, Harvard University, Cambridge, MA
1980-1981 Resident, Pathology, Brigham & Womens Hospital, Boston, MA
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Expertise:
- Biology and immunology of vascular endothelium; biology of cytokines; biological bases of disease
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Research Interests:
- My laboratory is interested in several related research problems addressing the immunobiology of vascular endothelium. First, we study how endothelial cells may promote the recruitment, activation and differentiation of T cells by presenting antigens. A major focus of this work is the identity of the molecules that endothelial cells use to provide costimulation. Second, we study how endothelial cells respond to cytokines such as TNF and acquire the capacity to recruit and activate inflammatory effector cells. A major focus of this work is the regulation of adhesion molecule expression.Third, we study how immune effector cells and molecules injure endothelial cells and how endothelial cells resist immune-mediated injury. Many of these processes are studied in the context of the host response to vascularized allografts or xenografts, and a major overall goal of this work is to develop strategies to improve clinical transplantation.
Immunopathology Transplantation Pathology
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Professional Service:
- 1981- American Association of Pathologists (renamed American Society
Investigative Pathology in 1993)
1984- American Association of Immunologists
1987- United States-Canadian Academy of Pathology
1994 - North American Vascular Biology Organization
1996- Fellow, Molecular Medicine Society
1994-1996 Councilor, North American Vascular Biology Organization
1996-1999 Councilor, American Society for Investigative Pathology
1996-1997 President-Elect, North American Vascular Biology Organization
1997-1998 President, North American Vascular Biology Organization
1995-2000 Co-Editor-in-Chief, Laboratory Investigation
2000-2002 Associate Editor, Laboratory Investigation
2000-2003 Editor, Immunity
2000- American Society of Transplant Surgeons
Other Links:
Community of Science (COS) Database
Selected Publications:Tellides, G., Tereb, D.A., Kirkiles-Smith, N.C., Kim, R.W., Wilson, J.H., Schechner, J.S., Lorber, M.I., Pober, J.S. Interferon-[gamma] elicits arteriosclerosis in the absence of leukocytes. Nature 403:207-211 (2000).
Mahboubi, K., Biedermann, B.C., Carroll, J.M., Pober, J.S. IL-11 activates human endothelial cells to resist immune-mediated injury. J. Immunol. 164:3837-3846 (2000).
Madge, L.A., Pober, J.S. A PI-3 kinase/Akt pathway, activated by TNF or IL-1 inhibits apoptosis but does not activate NF[kappa]B in human endothelial cells. J. Biol. Chem. 275:15458-15465 (2000).
Schechner, J.S., Nath, A.K., Zheng, L., Kluger, M.S., Hughes, C.C.W., Sierra-Honigmann, M.R., Lorber, M.I., Tellides, G., Kashgarian, M., Bothwell, A.L.M., Pober, J.S. In vivo formation of complex microvessels lined by human endothelial cells in an immunodeficient mouse. Proc. Natl. Acad Sci. USA. 97:9191-9196 (2000).
Feng, X., Gaeta, M.L., Madge, L.A., Yang, J-H., Bradley, J.R., Pober, J.S. Caveolin-1 associates with TRAF2 to form a complex that is recruited to TNF receptors. J. Biol. Chem. 276:8341-8349 (2001).
Search PubMed Database for Jordan Pober
This page was last modified on: 05/12/2008
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