John K. Rose, Ph.D.



Professor of Pathology and Cell Biology and
Director, Molecular Virology Program.

Department of Pathology
Yale University School of Medicine
P.O. Box 208023
310 Cedar St., BML339
New Haven, CT 06520-8023

Office: (203) 785-6184
Lab: (203) 785-6186
Fax: (203) 785-7467

email: john.rose@yale.edu


Training:
B.A. (Biology) Brandeis University, Waltham, MA, 1969
Predoctoral Trainee: US Public Health Service: Dr. Charles Yanofsky, Stanford University
Ph.D. (Biology & Biochemical Genetics) Stanford University, Palo Alto, CA, 1973
Postdoctoral Fellow: MIT: Drs. David Baltimore and Harvey Lodish 1974-78


Expertise:
Virology; vaccine and gene expression vectors based on rhabdoviruses; membrane protein assembly, transport and targeting; viral assembly.

Research Interests:
Vaccine development employing vectors based on recombinant negative-strand RNA viruses. Assembly of enveloped viruses. Specific targeting of viral vectors. Intracellular transport and targeting of viral and cellular membrane proteins.

Professional Service:
1980-1999 Editorial Board, Journal of Virology
1993-present Editorial Board, Virology
1994-1998: Member, ARRA AIDS Study Section
1993-1994: Ad hoc reviewer, ARR-1 AIDS Study Section
1992-2000 : Director, Yale Medical School HIV research core facility
1991: Co-chairman GORDON CONFERENCE ON ANIMAL CELLS AND VIRUSES
1987-1992: Director of Graduate Studies, Dept of Pathology
1988-1993 Negative-strand virus Editor for VIROLOGY

Other Links:

Community of Science (COS) Database

Selected Publications:

Rose, NF, Publicover, J, Chattopadhyay, A & Rose, JK (2008) Hybrid alphavirus-rhabdovirus propagating replicon particles are versatile and potent vaccine vectors. Proc Natl Acad Sci U S A 105, 5839-5843.

Ramsburg, EA, Publicover, JM, Coppock, D & Rose, JK (2007) Requirement for CD4 T cell help in maintenance of memory CD8 T cell responses is epitope dependent. J Immunol 178, 6350-6358.

Schwartz, JA, Buonocore, L, Roberts, A, Suguitan, A, Jr., Kobasa, D, Kobinger, G, Feldmann, H, Subbarao, K & Rose, JK (2007) Vesicular stomatitis virus vectors expressing avian influenza H5 HA induce cross-neutralizing antibodies and long-term protection. Virology 366, 166-173.

Ramsburg, E, Publicover, J, Buonocore, L, Poholek, A, Robek, M, Palin, A & Rose, JK (2005) A vesicular stomatitis virus recombinant expressing granulocyte-macrophage colony-stimulating factor induces enhanced T-cell responses and is highly attenuated for replication in animals. J Virol 79, 15043-15053.

Ramsburg, E, Rose, NF, Marx, PA, Mefford, M, Nixon, DF, Moretto, WJ, Montefiori, D, Earl, P, Moss, B & Rose, JK (2004) Highly effective control of an AIDS virus challenge in macaques by using vesicular stomatitis virus and modified vaccinia virus Ankara vaccine vectors in a single-boost protocol. J Virol 78, 3930-3940.

Rose, NF, Marx, PA, Luckay, A, Nixon, DF, Moretto, WJ, Donahoe, SM, Montefiori, D, Roberts, A, Buonocore, L & Rose, JK (2001) An effective AIDS vaccine based on live attenuated vesicular stomatitis virus recombinants. Cell 106, 539-549.





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This page was last modified on: 09/19/2008