Jeffrey  Sklar, M.D., Ph.D.

Training:

1970 B.A. (Biology) Haverford College, Haverford, PA
1977 M.D. School of Medicine, Yale University, New Haven, CT
1977 Ph.D. Molecular Biophysics/Biochemistry, Yale University, New Haven, CT
1977-79 Residency, Pathology, Stanford University Medical Center, Stanford, CA
1979-81 Post-doctoral Fellowship (Biochemistry), Stanford University, Stanford, CA
1992 M.A. (Honorary) Harvard University, Cambridge, MA

Expertise:

Molecular biology of human disease, especially cancer; molecular biologic methods of disease diagnosis; cancer-related genes and their functions in neoplasia and normal cellular physiology; chromosomal structure and chromosomal abnormalities in genetic and neoplastic disorders; immunogenetics.

Research Interests:

Development of new methods for the diagnosis of human diseases and conditions; molecular characterization of the structure and function of chromosomal aberrations in cancer; discovery of genes involved in neoplastic transformation of cells and in tumor progression, and the elucidation of the normal and dysregulated activities of those genes previously identified by this laboratory (including BCL2, NOTCH1, JAGGED2, MALT1, JAZF1, JJAZ1/SuZ[12]); investigation of the genetic and molecular mechanisms underlying the development and progression of cancers, particularly those of the lymphatic system and of the endometrium; Polycomb group genes and chromatin remodeling in cancer and normal development; epigenetic control of gene expression; trans-splicing of RNA.

Professional Service:

Assistant to Associate (tenured) Professor of Pathology, Stanford University School of Medicine, 1981-89
Committee on Fraud in Science, American Association of Medical Colleges, 1982
Director, Autopsy Service, Stanford University School of Medicine, 1984-86
Co-director, Molecular Diagnosis Service, Stanford University Medical Center, 1985-89
Pathology B Study Section, National Institutes of Health, 1986-1990, 1997, 2000
Test Committee on Molecular Biology, American Board of Pathology, 1987-89
Associate Professor to Professor of Pathology, Harvard Medical School, 1989-2003
Director, Division of Diagnostic Molecular Biology, Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts, 1989-2003
Co-chairman, Committee on the Utilization of Genetic Techniques in the Diagnosis and Prognosis of Cancer, National Institute of Medicine, 1991
Advisory Committee on the Clinical Sciences, Fred Hutchinson Cancer Center, Seattle, Washington, 1991-97
Scientific Advisory Committee, New England Primate Research Center, Harvard University, 1991-99
Director, Division of Molecular Oncolgy, Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts, 1992-2003
Award Committee, General Motors Sloan-Kettering Prize in Cancer Research, 1993
External Advisory Committee, Dana-Farber Cancer Institute, Boston, Massachusetts, 1993-97
Chairman, Clowes Award Committee, American Association for Cancer Research, 1996
Board of Scientific Counselors, Subcommittee A (Division of Clinical Sciences), National Institutes of Health/National Cancer Institute, 1996
Vice Director for Basic Sciences, Cancer Center, Brigham and Women's Hospital, 1997-2003
Professor of Pathology and Laboratory Medicine, Yale University School of Medicine, 2003-present
Director, Program in Molecular Diagnostics, Department of Pathology, Yale University School of Medicine, 2003-present
Co-Director, Program in Gene Regulation and Functional Genomics, Yale University Comprehensive Cancer Center, 2005-present
Past editorial board memberships: American Journal of Pathology; Leukemia; Genes, Chromosomes, and Cancer; American Journal of Surgical Pathology

Selected Publications: