Alexei A. Stortchevoi, Ph.D.



Associate Research Scientist in Pathology.


Department of Pathology
Yale University School of Medicine
P.O. Box 208023
310 Cedar St., LH108
New Haven, CT 06520-8023

Office: (203)785-4986
Lab: (203)785-4986
Fax: (203)785-6899

email: alexei.stortchevoi@yale.edu


Training:
2002: Research Associate, Harvard University Med. School, Dept. of Pathology, laboratory of prof. Sklar
1999-2002: Postdoctoral associate, MIT Dpt. of Biology, laboratories of prof's. RajBhandary and Khorana;
1997-1999: Postdoctoral associate, Boston University School of Medicine, Dpt. of Hematology-Oncology, laboratory of Dr. Rubinstein;
1992-1996: Ph.D. student, The University of Sydney (Sydney, Australia) Dpt. of Biochemistry, laboratory of prof. Weiss,
1985-1991: B.S. /M.S. student, Lomonosov State University (Moscow, Russia) , School of Biology, Dpt. of Bioorganic Chemistry


Expertise:
Biochemistry, Molecular and Cellular Biology

Research Interests:
In focus of my current research is transcription involving human NOTCH protein and DNA sequences of NOTCH-responding promoters.

Professional Service:
- as in "training" section, above

Other Links:

For presentation in Pasteur Institut (Paris, France), on topic: "Power and Thrill of Suppressor tRNA", Feb 10, 2003
Pubmed link

Selected Publications:

In preparation: Alexei Stortchevoi and Jeffrey Sklar: Transient Interaction of Intracellular NOTCH1 protein with CSL and HES1 promoter.

A.A. Stortchevoi. Misacylation of tRNA in prokaryotes: a re-evaluation.Cel. Mol. Life Sci. Vol. 63, Pages: 820 - 831, April 2006.

The abstract: T. Fernandez, C. Pellat-Deceunynck, S. Supiot, M. Cherel, A. Stortchevoi, R. Bataille, J.-L. Harousseau, D. B. Rubinstein and T. Guillaume. Selection of fully human anti-CD138 for detecting and therapy of multiple myeloma from combinatorial libraries and generation of novel anti-myeloma antibodies. Journal of Clinical Oncology, 2005 ASCO Annual Meeting Proceedings. Vol 23, No 16S (June 1 Supplement), 2005: 2550

Rubinstein DB, Stortchevoi A, Boosalis M, Ashfaq R, Ghebrehiwet B, Peerschke EI, Calvo F, Guillaume T. Receptor for the globular heads of C1q (gC1q-R, p33, hyaluronan-binding protein) is preferentially expressed by adenocarcinoma cells. Int J Cancer. 2004 Jul 10;110(5):741-50. PMID: 15146564 [PubMed - indexed for MEDLINE]

Alexei Stortchevoi, Umesh Varshney and Uttam RajBhandary: Common location of determinants in initiator transfer RNAs for initiator-elongator discrimination in bacteria and in eukaryotes. J Biol Chem. 2003 Mar 13 [epub ahead of print] PMID: 12639964 [PubMed - as supplied by publisher]

Daniel B. Rubinstein, Alexei Stortchevoi, Michael Boosalis, Raheela Ashfaq, and Thierry Guillaume: Over-expression of DNA-binding protein B (DbpB) gene product in breast cancer as detected by in vitro generated combinatorial human immunoglobulin libraries. Cancer Research, Issue 62, pp. 4985-4991, Sep. 1, 2002

Christine Mayer, Alexei Stortchevoi, Caroline Koehrer, Umesh Varshney and Uttam L. RajBhandary: Initiator tRNA and its role in initiation of protein synthesis. Cold Spring Harbor Symposia on Quantitative Biology, Vol. LXVI. 2001 Cold Spring Harbor Laboratory Press 0-87969-619-2/01

D. B. Rubinstein, P. Leblanc, D. G. Wright, T. Guillaume, A.A. Strotchevoi, and M. Boosalis. Anti-CD34+ Fabs generated against hematopoietic stem cells in HIV-derived combinatorial immunoglobulin library suggest antigen-selected autoantibodies. Molecular Immunology, Vol.35, No 14-15, October 1998

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This page was last modified on: 02/24/2010