YALE SCHOOL OF MEDICINE DEPARTMENT OF PATHOLOGY

For information about this site contact the webmaster

Yale Department of Pathology
PO Box 208023, LH108
New Haven CT, 06520-8023
203-785-2786

poster thumbnail

click to view larger pdf file

Interobserver Agreement in Interpreting Thyroid FNA with a Diagnosis of Atypia/Follicular Lesion of Undetermined Significance (FLUS/AUS)

Adebowale J. Adeniran1, Constanino Theoharis1, Mitchell Wachtel7, Zubair Baloch3, Marilyn Bui6, Isam Eltoum5, Oscar Lin4, Aylin Simsir8, Ed Stelow2, Guoping Cai1, Malini Harigopal1, Angelique Levi1, Berrin Ustun1, Meiklejohn McKenzie5, Diane Kowalski1, David Chhieng1

Departments of Pathology at: 1Yale School of Medicine, New Haven, CT; 2University of Virginia, Charlottesville, VA; 3University of Pennsylvania, Philadelphia, PA; 4Memorial Sloan-Kettering Cancer Center, New York, NY; 5University of Alabama, Birmingham, AL; 6Moffit Cancer Center, Miami, FL; 7Texas Tech University, Lubbock, TX; and 8New York University, New York, NY, USA

ABSTRACT

Background: The Bethesda System for Reporting Thyroid Cytopathology (BSRTC) was developed to refine definitions and improve clinical communication and management. However, the diagnostic category of atypia/follicular lesion of undetermined significance (FLUS/AUS) remains heterogeneous in terms of usage and clinical outcome. Because of the “gray zone” that exists in the interpretation of thyroid FNA demonstrating minor architectural and/or cytologic atypia, this study was undertaken to evaluate the degree of interobserver agreement in the evaluation of thyroid FNAs originally interpreted as FLUS/AUS.

Design: Twenty-three thyroid FNAs including 18 cases originally diagnosed as FLUS/AUS, 2 as negative for malignant cells, 2 as positive for malignancy, and 1 as follicular neoplasm were selected. Two repre-sentatives slides from each case were circulated to 13 board certified or eligible cytopathologists; all were from academic institutions with 6 were from the same institution. Each reviewer was asked to evaluate each cases using the BSRTC. The kappa statistics was calculated.

Results: Only 2 cases (22%) were in complete agreement: one originally interpreted as negative and one as positive for malignancy; both cases were confirmed on histology. There was a majority agreement (among 10 or more) in 6 cases: one originally diagnosed as positive, one negative, and 4 FLUS/AUS. Both positive and negative cases were confirmed on histology; among the 4 FLUS/AUS, 2 were found to be negative and 2 follicular adenoma on histology. For the entire group of reviewers, the mean kappa statistic was 0.34±0.13. The mean kappa statistic was 0.42±0.7 and 0.29±0.14 among reviewers of the same institution and among reviewers from different institutions. The difference was statistically significant.

Conclusions: The interobserver agreement for thyroid FNA cases originally classified as FLUS/AUS was fair among academic cytopathologists. It appeared that the interobserver agreement was better among cytopathologists who were from the same institution.

 

©2013 Yale Department of Pathology. All rights reserved.
Any redistribution or reproduction of part or all of the contents in any form is prohibited. You may not, except with express written permission of the author or the Department of Pathology, distribute or commercially exploit the content, nor may you transmit it or store it in any other website or other form of electronic retrieval system, including use for educational purposes.