CCN1 Expression in Ductal Proliferations: A Preliminary Study
Ozlen Saglam, MD1, Gokce Toruner MD2, G. Kenneth Haines III, MD1
1Department of Pathology, Yale School of Medicine, New Haven, CT and 2Institute of Genomic Medicine, University of Medicine and Dentistry of New Jersey, Newark, NJ, USA
ABSTRACT
CCN 1 is one the matricellular proteins that is aberrantly expressed in infiltrating duct carcinoma. We studied its possible role in intraepithelial duct proliferations. 6 Low Risk Ductal Intraepithelial Neoplasia, 18 Ductal Intraepithelial Neoplasia 1 (DIN1), 9 DIN2 and 10 DIN3 were studied by immunohistochemistry. All of the intermediate and high grade DIN cases showed either focal or diffuse positivity. 7 DIN1 cases were negative, 5 DIN1 were focally and 6 DIN1 were diffusely positive. The staining pattern was mostly cytoplasmic except in high grade DIN which had both cytoplasmic and nuclear staining. CCN 1 expression was independent of ER/PgR status of non-invasive lesions in this limited sample size.
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