YALE PATHOLOGY - Research Labs

Figure 3: Thrombospondin
Thrombospondin (TSP)-2 is an inhibitor of angiogenesis with pro-apoptotic and anti-proliferative effects on cultured endothelial cells. As a matricellular protein, TSP2 can modulate cell-matrix interactions and influence a number of processes including recovery from ischemia, wound healing, and the foreign body response. TSP2 has been shown to interact with a number of cell surface receptors, growth factors, extracellular matrix components, and enzymes. Thus, its participation in biological processes is thought to be complex.