Figure 3A & 3B
Hypoxia-induced endothelial BDNF
mediates endothelial survival and differentiation via an autocrine loop
and neural progenitor survival, proliferation and differentiation by a
paracrine loop, which then induces NPC NO, which in turn supports EC survival
and differentiation via a paracrine loop and NPC survival, proliferation
and differentiation via an autocrine loop.
Figure 3C
Hypoxia
induces EC BDNF, which in turn induces NPC, NO, via TrkB signaling, activating
a PI3K/Akt pathway, inducing expression and activation of eNOS. NO signaling,
in turn, stabilizing HIF-1alpha and decreases Prolyl Hydroxylase Domain
2, inducing persistent EC BDNF (and VEGF & SDF-1), which facilitate
continued NO generation and NPC survival, proliferation and differentiation.