Yale Pathology Morrow Lab

Research

Central to the integrated function of multicellular organisms is cell contact mediated signaling and the spatial organizations of specialized membrane-surface domains. While many factors contribute, recent evidence indicates that the spectrin based membrane skeleton plays a pivotal role in these processes. Current research in the laboratory is aimed at understanding three aspects of the spectrin membrane skeleton in erythrocytes, epithelial cells, and neurons: 1) The factors that mediate its polarized assembly with specific surface membrane receptor domains; 2) the nature of the proteins that interact with spectrin and their role in signal transduction, cell differentiation, vesicle trafficking, and topographic membrane assembly; and 3) the molecular basis of diseases that involve spectrin or any of its associated proteins, including contributions of the cortical cytoskeleton to the phenotypic alterations of malignant cells and the molecular pathology of acquired and inherited disorders involving this structure. Our studies on the erythrocyte focus on a molecular understanding of how specific proteins that cause human disease.

Hemolytic Disease, Degenerative Brain Disease, spectrin, Autopsy Pathology, Renal Pathology, Medical Informatics, Computer Aided Instruction (CAI), Telepathology

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People

Current members of the Morrow laboratory:

	Jon S. Morrow, M.D., Ph.D. Chairman and Chief of Pathology
	Carol Cianci, Ph.D. Associate Research Scientist
	Michael Stankewich, Ph.D. Associate Research Scientist
	Tom Ardito Research Associate
	Lan Ji Research Associate
	Paul Stabach, B.S. Research Associate

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Publications

Pradhan D, Morrow J. The spectrin-ankyrin skeleton controls CD45 surface display and interleukin-2 production. Immunity. 2002 Sep;17(3):303-15.
Nedrelow JH, Cianci CD, Morrow JS. c-Src binds alpha II spectrin's SH3 domain and blocks calpain susceptibility by phosphorylating Tyr1176. J Biol Chem. 2002 Nov 20
Curristin SM, Cao A, Stewart WB, Zhang H, Madri JA, Morrow JS, Ment LR. Disrupted synaptic development in the hypoxic newborn brain. Proc Natl Acad Sci U S A. 2002 Nov 26;99(24):15729-34.
Siddhanta A, Radulescu A, Stankewich MC, Morrow JS, Shields D. Fragmentation of the Golgi apparatus: A role for III spectrin and synthesis of phosphatidylinositol(4,5)bisphosphate. J Biol Chem. 2002 Oct 30
Woroniecki R, Ferdinand JR, Morrow JS, Devarajan P. Dissociation of Spectrin-Ankyrin Complex as a Basis for Loss of Na,K-ATPase Polarity Following Ischemia In MDCK Cells. Am J Physiol Renal Physiol. 2002 Oct 29
Schwartz MF, Duong JK, Sun Z, Morrow JS, Pradhan D, Stern DF. Rad9 phosphorylation sites couple Rad53 to the Saccharomyces cerevisiae DNA damage checkpoint. Mol Cell. 2002 May;9(5):1055-65.
Morrow JS, Costa J. Fifty years of Laboratory Investigation: chronicle of a blossoming discipline. Lab Invest. 2002 Jan;82(1):3-4.
Huh GY, Glantz SB, Je S, Morrow JS, Kim JH. Calpain proteolysis of alpha II-spectrin in the normal adult human brain. Neurosci Lett. 2001 Dec 4;316(1):41-4.
Zhang Z, Weed SA, Gallagher PG, Morrow JS. Dynamic molecular modeling of pathogenic mutations in the spectrin self-association domain. Blood. 2001 Sep 15;98(6):1645-53.
Holleran EA, Ligon LA, Tokito M, Stankewich MC, Morrow JS, Holzbaur EL. beta III spectrin binds to the Arp1 subunit of dynactin. J Biol Chem. 2001 Sep 28;276(39):36598-605.
Giorgi M, Cianci CD, Gallagher PG, Morrow JS. Spectrin oligomerization is cooperatively coupled to membrane assembly: a linkage targeted by many hereditary hemolytic anemias? Exp Mol Pathol. 2001 Jun;70(3):215-30.
Lee A, Morrow JS, Fowler VM. Caspase remodeling of the spectrin membrane skeleton during lens development and aging. J Biol Chem. 2001 Jun 8;276(23):20735-42.
Sinard JH, Morrow JS. Informatics and anatomic pathology: meeting challenges and charting the future. Hum Pathol. 2001 Feb;32(2):143-8. Review. No abstract available.
De Matteis MA, Morrow JS. ADP-ribosylation factor (ARF) as regulator of spectrin assembly at Golgi complex. Methods Enzymol. 2001;329:405-16. No abstract available.
Muresan V, Stankewich MC, Steffen W, Morrow JS, Holzbaur EL, Schnapp BJ. Dynactin-dependent, dynein-driven vesicle transport in the absence of membrane proteins: a role for spectrin and acidic phospholipids. Mol Cell. 2001 Jan;7(1):173-83.
Pradhan D, Lombardo CR, Roe S, Rimm DL, Morrow JS. alpha -Catenin binds directly to spectrin and facilitates spectrin-membrane assembly in vivo. J Biol Chem. 2001 Feb 9;276(6):4175-81

Research

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People

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